Twenty-Year Outcomes after Breast-Conserving Surgery and Definitive Radiotherapy for Mammographically detected DCIS
Adjuvant radiation therapy has been shown to reduce recurrent disease in patients with invasive breast cancer. This study reports the long-term clinical outcome (ipsylateral breast tumor recurrence (IBTR), contralateral breast failure, disease-free survival, cancer-specific survival, and overall survival) for patients with mammographically detected noninvasive DCIS with no breast-related symptoms. All patients were treated with surgical excision followed by external beam radiation.
A total of 129 cases were retrospectively evaluated with a median follow-up of 19.3 years. Invasive or non-invasive recurrent disease occurred in 16.4% of patients after 20 years. It was shown that a young age at diagnosis (>45 years) was predictive for recurrence within the first 10 years while a larger tumor size (≤ 7mm) and an increased number of DCIS ducts were predictive for recurrence after more than 10 years. The overall survival was 96.8 % after 20 years.
Link: http://www.ncbi.nlm.nih.gov/pubmed/22644510
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